PI: Tanja Kuhlmann
INSTITUTE Westfälische Wilhelms-Universit-ät Münster
ADDRESS Schlossplatz 2, 48149 Münster
The Kuhlmann lab has a strong background in MS neuropathology and oligodendroglial biology. It has published several studies analyzing the histopathology of MS lesions with a special focus on oligodendroglial as well as axonal damage and repair mechanisms. They established markers to identify different oligodendroglial populations in developmental and in adult human tissue samples including early and chronic MS lesions. To be able to understand the mechanisms underlying the pathological characteristics of MS lesions and to address functional questions in oligodendroglial biology, the Kuhlmann lab studies the regulation of oligodendroglial migration, differentiation and cell death in vitro and in vivo. They identified indomethacin as a compound that promotes oligodendroglial differentiation as well as remyelination, at least partly by inhibiting the Wnt/b-catenin signalling pathway. In order to translate their findings back from murine to human cells the Kuhlmann lab established a fast, reliable and reproducible protocol to generate oligodendrocytes from human induced pluripotent stem cells.
Pertinent to the proposal, Kuhlmann lab will be responsible of implementing in vivo and in vitro models of demyelination (murine and human) as well as of assessing pathological validation in human preserved pathological samples.